







Product description

SKINCARE WITH EXPERIENCE The Perricone MD Neuropeptide Collection
Our most powerful high-performance skincare range developed from over twenty-five years of research. Specifically designed to address mature skin concerns such as sagging skin, deep wrinkles and loss of elasticity. These advanced formulas improve skin elasticity and restore visible skin firmness.


RETHINKING AGING When Does a Wrinkle Become a Crease?
Repeated facial movements gradually carve out expression lines into the skin. With age, these dynamic wrinkles stand out more, most often near the eyes, forehead, cheeks and mouth.
The video showcases the product in use.The video guides you through product setup.The video compares multiple products.The video shows the product being unpacked. Perricone MD Neuropeptide Eyelid Lift Serum Merchant Video
Package Dimensions : 4.69 x 2.32 x 1.54 inches; 3.53 ounces
UPC : 651473716327
Manufacturer : Perricone MD
ASIN : B0GJB278H6
Best Sellers Rank: #81,942 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #1,629 in Facial Serums
Customer Reviews: 4.7 4.7 out of 5 stars (32) var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Addresses creases, deep wrinkles, expression lines, crepiness, and discoloration.

Holly E. –
It takes time and daily routine
So far it’s working great!
Amber Norell –
Hydrating Serum with No Greasy Residue – Balanced Feel, Gradual Results
This serum stands out to me for how lightweight it feels and how easily it absorbs into my skin. It doesn’t leave behind any greasy or oily residue, which makes it feel comfortable to layer into a routine without adding heaviness.The texture is very fluid without being overly watery, and the dropper bottle makes it simple to control how much I dispense. The packaging feels sturdy and secure, and I haven’t had any issues with leaking from the dropper. That said, I’m still cautious with dropper bottles in general based on prior experiences, so if I travel with it, I plan to keep it upright and sealed in a plastic bag just to be safe. The bottle itself is small, but a little goes a long way, so it feels like something that will last me quite a while.In terms of how it sits on my skin, it does seem to add hydration and leaves my skin looking a bit more supple after application. It also appears to support areas with fine lines and wrinkles, although I noticed that it takes time and consistent use before seeing more noticeable changes, including a firmer look. This isn’t something that shows immediate results without regular use, so it does require some discipline to keep up with.I also noticed the ingredient profile includes some of the basics I tend to look for, like niacinamide and glycerin, along with more advanced components such as neuropeptides, biomimetic growth factor peptides, and plant stem cells. The formula feels more complex compared to many other wrinkle-focused products I’ve come across. This serum is also very gentle and didn’t have any harsh, irritating or overpowering fragrances.There are a couple of considerations. The cost is on the higher side for a one ounce bottle, and the need for consistent use is important if you’re expecting visible changes. Because a little goes a long way, it may make sense to focus on specific areas if you’re trying to fully evaluate how it works on your skin. Overall, I’ve been enjoying having this in my routine and appreciate the combination of lightweight texture, thoughtful packaging, and effective ingredients.
Palina –
You May Not Know It Yet, But You Love This One
I am SO impressed with this serum. I was happy to see it came with a tamper resistant seal in place, that is really important to me. I didn’t really notice a scent with this one, if there was one, it was faint enough that the other products I use have more of a fragrance that I couldn’t detect one on this one, so little, to no fragrance, which is nice.It’s really easy to use, I just use the dropper to put a little on the back of one of my hands & then dip my fingertips into it. Then I use my fingertips to massage it into the areas I need help. There is a little guide in the box on how to massage in in, which helps. It absorbs in pretty quickly, it really only takes a few seconds, it goes from feeling slippery, to slightly tacky, to soft & light in just a few moments.A little also goes a long way, I use it right out of the shower, after micellar water, so, my skin is already slippery, so, that probably helps too. You just sort of massage it in an upward motion for a few seconds & it really does a great job of making your fine lines look less noticeable. It says you can moisturize afterwards, you really don’t have to if you don’t want to, your skin feels okay afterward, although I do anyway as it’s just a part of my routine that I would normally do because of adding spf.I have been using this for a few weeks now & there is actually a noticeable difference. I live in a very cold climate & have to fight damage from harsh dry, agin, winter skin, ugh lol. This has been SO wonderful. The skin around my eyes and laugh lines are giving more “happy” and less “haggard” haha. I really needed this, it’s such a treat to feel good when I look in the mirror again.This is a more expensive treatment, but, as I said, a little goes a long way. I have only been using a drop or two each time since my skin is already pre-moistened before I begin, so, I believe it’s worth every penny. I am SO happy to have found this.
Ashley –
Great facial serum for deep wrinkles!
This perricone MD Deep Crease Serum has become a daily part of my nigh-time skincare routine. The serum is super lightweight and lux. The applicator is excellent for apply to the skin – it’s an eyedropper that is very easy to use. There isn’t really any smell to the serum and it seems like it melts into my skin very easily after application. I have been applying it mostly around my eyes and on my forehead to try to decrease the wrinkles I have there and I feel like it has definitely moisturized my skin a good amount over the last few months and has been effective in making the skin feel more hydrated. The price is slightly on the higher side, however I will say that a little goes a LONG way and it has lasted me several months so far so the price is justified for an effective and high end serum. It arrived on time and well packaged and I will be purchasing again once I am done with this bottle. I recommend!
Bridget b –
Noticeable Results on Fine Lines – Worth Trying
The serum has a lightweight, silky consistency that absorbs quickly without leaving a greasy residue, which makes it easy to layer under makeup or other skincare products.After consistent use, I noticed my deeper smile lines and forehead creases appear softer and less pronounced. My skin also feels more hydrated and plump. I did not experience any irritation, which is a huge plus for my sensitive skin.The only reason I didn’t give it five stars is the price—this is definitely an investment serum. But if you’re looking for a high-quality product that targets fine lines and helps improve skin elasticity, it’s worth considering.Highly recommend for those wanting a targeted anti-aging boost